In vivo Experiments
Causal Molecular Mechanisms Linking Drinking Water Metal Exposures to Cardiometabolic Disease
Arsenic and uranium are major contaminants at Superfund sites, and exposure to these contaminants can partly explain the excess burden of cardiometabolic disease affecting Native American communities in the US. Project 4 will determine the physiological and molecular pathways linking arsenic and uranium exposures to cardiometabolic disease phenotypes using tractable transgenic mouse models. This study provides detailed and expansive insight into the developmental and life-long influences of these metals exposures and create a novel experimental system to test interventions to protect highly exposed populations in the US Northern Plains.