Strong Heart Study
![Columbia Northern Plains Superfund Research Program Project 3](https://www.publichealth.columbia.edu/sites/default/files/styles/cola_media_200/public/media/images/2023-03/ehs_superfund_project_3.jpg?itok=XmWGfbj8 200w, https://www.publichealth.columbia.edu/sites/default/files/styles/cola_media_260/public/media/images/2023-03/ehs_superfund_project_3.jpg?itok=rkREAu6g 260w, https://www.publichealth.columbia.edu/sites/default/files/styles/cola_media_320/public/media/images/2023-03/ehs_superfund_project_3.jpg?itok=wy-DCJ1r 320w, https://www.publichealth.columbia.edu/sites/default/files/styles/cola_media_400/public/media/images/2023-03/ehs_superfund_project_3.jpg?itok=QoN4eBJ- 400w, https://www.publichealth.columbia.edu/sites/default/files/styles/cola_media_520/public/media/images/2023-03/ehs_superfund_project_3.jpg?itok=aiBJ43VK 520w, https://www.publichealth.columbia.edu/sites/default/files/styles/cola_media_640/public/media/images/2023-03/ehs_superfund_project_3.jpg?itok=XyDT3GAP 640w, https://www.publichealth.columbia.edu/sites/default/files/styles/cola_media_1600/public/media/images/2023-03/ehs_superfund_project_3.jpg?itok=_AZGt4rE 782w, https://www.publichealth.columbia.edu/sites/default/files/styles/cola_media_800/public/media/images/2023-03/ehs_superfund_project_3.jpg?itok=eexLUVDA 800w, https://www.publichealth.columbia.edu/sites/default/files/styles/cola_media_1040/public/media/images/2023-03/ehs_superfund_project_3.jpg?itok=tbuDwxfv 1040w, https://www.publichealth.columbia.edu/sites/default/files/styles/cola_media_1280/public/media/images/2023-03/ehs_superfund_project_3.jpg?itok=VFFyxIld 1280w)
Health Effects of Metals in Native American Communities: A Longitudinal Multi-omics Study
Arsenic and uranium are major contaminants at Superfund sites, and exposure to these contaminants can partly explain the excess burden of cardiometabolic disease affecting Native American communities in the US. Project 3 will determine the effect of past and current metal exposures in cardiometabolic disease and their longitudinal epigenetic and metabolomic signatures. This study can then reveal molecular mechanisms for metal-induced health effects, identify susceptible populations, and inform risk assessment with direct benefits for the prevention and control of metal exposure and cardiometabolic disease affecting tribal communities in the US Northern Plains as well as other at-risk populations globally.