Nicole Schupf

Nicole Schupf

Nicole Schupf

Epidemiology (in Neurology, Psychiatry, the Gertrude H. Sergievsky Center, and the Taub Institute) at the Columbia University Medical Center


Taub Institute, P.O. Box 16, 630 West 168th Street
New York


Dr. Nicole Schupf conducts studies of aging and Alzheimer's disease in adults with Down syndrome and shared genetic susceptibility to Down syndrome and Alzheimer's disease in mothers of adults with Down syndrome. This includes the relation of genetic and host factors to age at onset and risk for Alzheimer's disease. Dr. Schupf's recent work focuses specifically on the relationship between estrogen deficiency, indicated by age at onset of menopause, apolipoprotein E gentoype and age at onset of Alzheimer's disease in women with Down syndrome.



DrPH, 1995, Columbia Univsersity
MPH, 1984, University of California
PhD, 1970, New York University
BA, 1964, Bryn Mawr College

Editorial Boards

Consulting Editor, Mental Retardation

Other Affiliations

American College of Epidemiology
Fellow, American Association on Mental Retardation
American Academy of Neurology
Society for Epidemiologic Research

Honors & Awards

Anna C. Gelman award for Excellence in Epidemiology, Columbia University, 1995
The Blake Marsh Lecture. Genetic and host factors for accelerated ageing and dementia in Down syndrome. Royal College of Psychiatry Annual Meeting, Edinburgh, Scotland, July 7, 2000

Areas of Expertise

Neurodevelopmental Disorders, Neurological Disease / Disorders

Select Urban Health Activities

Epidemiology of menopause and dementia in Down syndrome: This project exmaines the relation of estrogen and Alzheimer's disease in a community based sample of women with Down syndrome, who reside in the none-county downstate New York region.

Select Global Activities

Beta amyloid protein and dementia in Down syndrome: This project will determine whether elevations of beta amyloid proein in the blood can serve as an early marker of incipient dementia in adults with Down syndrome.

Select Publications

Silverman W, Schupf N, Zigman W, Devenny D, Miezejeski C, Schubert R, Ryan R Dementia in adults with mental retardation: assessment at a single point of time American Journal of Mental Retardation 111-125 2004 109
Patel BN, Pang D, Stern Y, Silverman W, Kline JK, Mayeux R, Schupf N Obesity enhances verbal memory in postmenopausal women with Down syndrome Neurobiology of Aging 159-166 2004 25
Schupf N, Pang D, Patel BN, Silverman W, Schubert R, Lai F, Kline JK, Stern T, Ferin M, Tycko B, Mayeux R Onset of dementia is associated with age at menopause in women with Down syndrome Annals of Neurology 433-438 2003 54
Mayeux R, Honig LS, Tang M-X, Manly J, Stern Y, Schupf N, Mehta PD Plasma Amyloid Ab40 and Ab42 and Alzheimer's Disease (AD). Relation to Age and Mortality Neurology 1185-1190 2003 61
Schupf N Genetic and host factors for dementia in Down syndrome British Journal of Psychiatry 405-410 2002 180
Lee JH, Tang M-X, Schupf N, Stern Y, Jacobs D, Tycko B, Mayeux R Mortality and apolipoprotein E in Hispanics, African-Americans and Caucasians American Journal of Medical Genetics 121-131 2001 103
Patel BN, Seltzer G, Wu H-S, Schupf N Effect of menopause on cognitive performance in women with Down syndrome NeuroReport 2659-2662 12
Schupf N, Patel BN, Silverman W, Zigman W, Zhong N, Tycko B, Mehta PD, Mayeux R Elevated plasma amyloid b-peptide 1-42 and onset of dementia in Down syndrome Neuroscience Letters 199-203 2001 301
Schupf N, Zigman W, Kapell D, Lee JH, Kline JK, Levin B Early menopause in women with Down syndrome Journal of Intellectual Disability Research 264-267 1997 41
Schupf N, Kapell D, Lee JH, Ottman R, Mayeux R Increased risk of Alzheimer's disease in mothers of adults with Down syndrome Lancet 353-356 1994 334

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