Gary W. Miller, PhD
- Adrienne Block Professor of Environmental Health Sciences (in Molecular Pharmacology and Therapeutics)
- Vice Dean for Research Strategy and Innovation, Mailman School of Public Health
On the web
Overview
Dr. Miller is a leader in the field of exposomics, which studies the comprehensive and cumulative effects of physical, chemical, biological, and psychosocial mediators that impact biological systems. He has helped develop high-resolution mass spectrometry methods to provide an -omic scale analysis of the human exposome. He serves on the advisory panel to the National Institutes of Health All of Us Research Program. Dr. Miller is the founding editor of the journal Exposome. He previously served as the Editor of Toxicological Sciences.
In 2026, Dr. Miller was featured on The LIVING Room, a podcast from The WNDR LAB. https://www.youtube.com/watch?v=tjk8wwN1bGE&t=16s
Office Location: 722 West 168th Street, ARB 1411B
Academic Appointments
- Adrienne Block Professor of Environmental Health Sciences (in Molecular Pharmacology and Therapeutics)
- Vice Dean for Research Strategy and Innovation, Mailman School of Public Health
Administrative Titles
- Co-Director, Precision Medicine Core, Irving Institute
- Director, Center for Innovative Exposomics
Credentials & Experience
Education & Training
- BS, 1989 Old Dominion University
- MS, 1992 Old Dominion University
- PhD, 1995 University of Georgia
- 1997 Emory University
- 1998 Duke University
Committees, Societies, Councils
NIH All of Us Research Program Advisory Panel
Editorial Boards
Exposome, Editor-in-Chief (2021-present)
Toxicological Sciences, Editor-in-Chief (2013-2019)
Research
Research Interests
- Exposomics
- Neurodegeneration
- Toxicology
Selected Publications
Books
Miller GW. The Exposome: A New Paradigm for the Environment and Health. Academic Press, Elsevier, Published June, 2020, 298 pages.
Miller, G.W. The Exposome: A Primer. Academic Press, Elsevier, New York, 2014. 110 pages
Papers
Patel CJ, Miller GW, Motsinger-Reif AA. Vision for exposomics-scale investigation: a heuristic for exposure-wide association studies (ExWAS). Environ Sci Technol. 2026 May 27. doi: 10.1021/acs.est.6c02553.
Miller GW, Habre R, Patel CJ. Exposomics crosses the Rubicon: let the building begin. Environ Sci Technol. 2026 May 12;60(18):13245-13248. doi: 10.1021/acs.est.6c02721.
Kalia V, Manz KE, Benavides J, Song S, Vollmer BL, Yan B, Goldsmith J, Pennell KD, Stern Y, Kioumourtzoglou MA, Miller GW, Habeck C, Gu Y. Mixture of organic pollutants is associated with cognitive aging. Alzheimers Dement. 2026 Apr;22(4):e71399. doi: 10.1002/alz.71399.
Dinehart C, Delaney SW, Mock L, Racette BA, Miller GW, Kioumourtzoglou MA, Braun D, Zanobetti A, Mork D. Extreme heat and hospitalization with Parkinson's disease among older adults. J Expo Sci Environ Epidemiol. 2026 Apr 13. doi: 10.1038/s41370-026-00882-7.
Kalia V, Reyes-Dumeyer D, Dubey S, Udhani H, Nandakumar R, Lee AJ, Lantigua R, Medrano M, Rivera D, Honig LS, Mayeux R, Miller GW, Vardarajan BN. Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer's disease. Nature Aging. 2026 Jan;6(1):221-234. doi: 10.1038/s43587-025-01025-7.
Miller GW; Banbury Exposomics Consortium. Integrating exposomics into biomedicine. Science. 2025 Apr 25;388(6745):356-358. doi: 10.1126/science.adr0544
Lai Y, Reina-Gonzalez P, Maor G, Miller GW, Sarkar S. Biotin mitigates the development of manganese-induced, Parkinson's disease-related neurotoxicity in Drosophila and human neurons. Science Signaling. 2025 Jan 21;18(870):eadn9868. doi: 10.1126/scisignal.adn9868
Miller GW. Exposomics: perfection not required. Exposome. 2024 Oct 4;4(1):osae006. doi: 10.1093/exposome/osae006.
Lai Y, Koelmel JP, Walker DI, Price EJ, Papazian S, Manz KE, Castilla-Fernández D, Bowden JA, Nikiforov V, David A, Bessonneau V, Amer B, Seethapathy S, Hu X, Lin EZ, Jbebli A, McNeil BR, Barupal D, Cerasa M, Xie H, Kalia V, Nandakumar R, Singh R, Tian Z, Gao P, Zhao Y, Froment J, Rostkowski P, Dubey S, Coufalíková K, Seličová H, Hecht H, Liu S, Udhani HH, Restituito S, Tchou-Wong KM, Lu K, Martin JW, Warth B, Godri Pollitt KJ, Klánová J, Fiehn O, Metz TO, Pennell KD, Jones DP, Miller GW. High-resolution mass spectrometry for human exposomics: expanding chemical space coverage. Environ Sci Technol. 2024 Jul 23;58(29):12784-12822. doi: 10.1021/acs.est.4c01156.
Bucher ML, Dunn AR, Bradner JM, Egerton KS, Burkett JP, Johnson MA, Miller GW. Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity. Eur J Neurosci. 2024 May;59(10):2483-2501. doi: 10.1111/ejn.16311. Epub 2024 Mar 26.
Kalia V, Kulick ER, Vardarajan B, Gu Y, Manly JJ, Elkind MSV, Kaufman JD, Jones DP, Baccarelli AA, Mayeux R, Kioumourtzoglou MA, Miller GW. Linking air pollution exposure to blood-based metabolic features in a community-based aging cohort with and without dementia. J Alzheimers Dis. 2023;96(3):1025-1040.
Koelmel JP, Xie H, Price EJ, Lin EZ, Manz KE, Stelben P, Paige MK, Papazian S, Okeme J, Jones DP, Barupal D, Bowden JA, Rostkowski P, Pennell KD, Nikiforov V, Wang T, Hu X, Lai Y, Miller GW, Walker DI, Martin JW, Godri Pollitt KJ. An actionable annotation scoring framework for gas chromatography-high-resolution mass spectrometry. Exposome. 2022 Aug 25;2(1):osac007.
Vermeulen R, Schymanski E, Barabási AL, Miller GW. The exposome and health: where chemistry meets biology. Science, 367:392-396, 2020.
Dunn AR, Stout KA, Lohr KM, Hoffman C, Bernstein AI, Li Y, Wang M, Sgobio C, Sastry, N, Cai H, Caudle WM, Miller G.W. (2017) Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease. Proceedings of the National Academy of Sciences. Mar 14;114(11):E2253-E2262. *Highlighted in This Week in the Journal.
Lohr KM, Bernstein AI, Stout KA, Dunn AR, Lazo CR, Alter SP, Wang M, Li Y, Fan X, Hess EJ, Yi H, Vecchio LM, Goldstein DS, Guillot TS, Salahpour A, Miller GW. (2014) Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson’s disease-related neurodegeneration in vivo. Proceedings of the National Academy of Sciences. 111:9977. *Highlighted in “This Week in PNAS.”
Miller GW. The Exposome: A New Paradigm for the Environment and Health. Academic Press, Elsevier, Published June, 2020, 298 pages.
Miller, G.W. The Exposome: A Primer. Academic Press, Elsevier, New York, 2014. 110 pages
Papers
Patel CJ, Miller GW, Motsinger-Reif AA. Vision for exposomics-scale investigation: a heuristic for exposure-wide association studies (ExWAS). Environ Sci Technol. 2026 May 27. doi: 10.1021/acs.est.6c02553.
Miller GW, Habre R, Patel CJ. Exposomics crosses the Rubicon: let the building begin. Environ Sci Technol. 2026 May 12;60(18):13245-13248. doi: 10.1021/acs.est.6c02721.
Kalia V, Manz KE, Benavides J, Song S, Vollmer BL, Yan B, Goldsmith J, Pennell KD, Stern Y, Kioumourtzoglou MA, Miller GW, Habeck C, Gu Y. Mixture of organic pollutants is associated with cognitive aging. Alzheimers Dement. 2026 Apr;22(4):e71399. doi: 10.1002/alz.71399.
Dinehart C, Delaney SW, Mock L, Racette BA, Miller GW, Kioumourtzoglou MA, Braun D, Zanobetti A, Mork D. Extreme heat and hospitalization with Parkinson's disease among older adults. J Expo Sci Environ Epidemiol. 2026 Apr 13. doi: 10.1038/s41370-026-00882-7.
Kalia V, Reyes-Dumeyer D, Dubey S, Udhani H, Nandakumar R, Lee AJ, Lantigua R, Medrano M, Rivera D, Honig LS, Mayeux R, Miller GW, Vardarajan BN. Lysophosphatidylcholines are associated with amyloidosis in early stages of Alzheimer's disease. Nature Aging. 2026 Jan;6(1):221-234. doi: 10.1038/s43587-025-01025-7.
Miller GW; Banbury Exposomics Consortium. Integrating exposomics into biomedicine. Science. 2025 Apr 25;388(6745):356-358. doi: 10.1126/science.adr0544
Lai Y, Reina-Gonzalez P, Maor G, Miller GW, Sarkar S. Biotin mitigates the development of manganese-induced, Parkinson's disease-related neurotoxicity in Drosophila and human neurons. Science Signaling. 2025 Jan 21;18(870):eadn9868. doi: 10.1126/scisignal.adn9868
Miller GW. Exposomics: perfection not required. Exposome. 2024 Oct 4;4(1):osae006. doi: 10.1093/exposome/osae006.
Lai Y, Koelmel JP, Walker DI, Price EJ, Papazian S, Manz KE, Castilla-Fernández D, Bowden JA, Nikiforov V, David A, Bessonneau V, Amer B, Seethapathy S, Hu X, Lin EZ, Jbebli A, McNeil BR, Barupal D, Cerasa M, Xie H, Kalia V, Nandakumar R, Singh R, Tian Z, Gao P, Zhao Y, Froment J, Rostkowski P, Dubey S, Coufalíková K, Seličová H, Hecht H, Liu S, Udhani HH, Restituito S, Tchou-Wong KM, Lu K, Martin JW, Warth B, Godri Pollitt KJ, Klánová J, Fiehn O, Metz TO, Pennell KD, Jones DP, Miller GW. High-resolution mass spectrometry for human exposomics: expanding chemical space coverage. Environ Sci Technol. 2024 Jul 23;58(29):12784-12822. doi: 10.1021/acs.est.4c01156.
Bucher ML, Dunn AR, Bradner JM, Egerton KS, Burkett JP, Johnson MA, Miller GW. Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity. Eur J Neurosci. 2024 May;59(10):2483-2501. doi: 10.1111/ejn.16311. Epub 2024 Mar 26.
Kalia V, Kulick ER, Vardarajan B, Gu Y, Manly JJ, Elkind MSV, Kaufman JD, Jones DP, Baccarelli AA, Mayeux R, Kioumourtzoglou MA, Miller GW. Linking air pollution exposure to blood-based metabolic features in a community-based aging cohort with and without dementia. J Alzheimers Dis. 2023;96(3):1025-1040.
Koelmel JP, Xie H, Price EJ, Lin EZ, Manz KE, Stelben P, Paige MK, Papazian S, Okeme J, Jones DP, Barupal D, Bowden JA, Rostkowski P, Pennell KD, Nikiforov V, Wang T, Hu X, Lai Y, Miller GW, Walker DI, Martin JW, Godri Pollitt KJ. An actionable annotation scoring framework for gas chromatography-high-resolution mass spectrometry. Exposome. 2022 Aug 25;2(1):osac007.
Vermeulen R, Schymanski E, Barabási AL, Miller GW. The exposome and health: where chemistry meets biology. Science, 367:392-396, 2020.
Dunn AR, Stout KA, Lohr KM, Hoffman C, Bernstein AI, Li Y, Wang M, Sgobio C, Sastry, N, Cai H, Caudle WM, Miller G.W. (2017) Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease. Proceedings of the National Academy of Sciences. Mar 14;114(11):E2253-E2262. *Highlighted in This Week in the Journal.
Lohr KM, Bernstein AI, Stout KA, Dunn AR, Lazo CR, Alter SP, Wang M, Li Y, Fan X, Hess EJ, Yi H, Vecchio LM, Goldstein DS, Guillot TS, Salahpour A, Miller GW. (2014) Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson’s disease-related neurodegeneration in vivo. Proceedings of the National Academy of Sciences. 111:9977. *Highlighted in “This Week in PNAS.”
Global Health Activities
International Collen-Francqui Chair, Visiting Professorship. Ghent University, Antwerp University, KU Leuven, Hasselt University, and the University of Liège, Belgium. March-July, 2026. https://www.ugent.be/fw/internationalcollenfrancqui
EIRENE: European Strategy Forum for Scientific Infrastructures. Dr. Miller leads the Columbia University hub of this European Consortium designed to support the development and harmonization of exposomics.
Visiting Professor, University of Paris Descartes, France: Visiting Professor at the University of Paris Descartes in Spring 2018. I continue to collaborate with colleagues at the University and at Inserm.
EIRENE: European Strategy Forum for Scientific Infrastructures. Dr. Miller leads the Columbia University hub of this European Consortium designed to support the development and harmonization of exposomics.
Visiting Professor, University of Paris Descartes, France: Visiting Professor at the University of Paris Descartes in Spring 2018. I continue to collaborate with colleagues at the University and at Inserm.
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