Gary W. Miller, PhD

  • Adrienne Block Professor of Environmental Health Sciences (in Molecular Pharmacology and Therapeutics)
  • Vice Dean for Research Strategy and Innovation, Mailman School of Public Health
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Overview

Dr. Miller is a leader in the field of exposomics, which studies the comprehensive and cumulative effects of physical, chemical, biological, and psychosocial mediators that impact biological systems. He has helped develop high-resolution mass spectrometry methods to provide an -omic scale analysis of the human exposome. He serves on the advisory panel to the National Institutes of Health All of Us Research Program and on the National Environmental Health Sciences Advisory Council. Dr. Miller is the founding editor of the journal Exposome. He previously served as the Editor of Toxicological Sciences.

In 2024, Dr. Miller was featured on Tomorrow’s Cure: How a lifetime of exposures impact health – exposome explained, a Mayo Clinic podcast.

Office Location: 722 West 168th Street, ARB 1411B

Academic Appointments

  • Adrienne Block Professor of Environmental Health Sciences (in Molecular Pharmacology and Therapeutics)
  • Vice Dean for Research Strategy and Innovation, Mailman School of Public Health

Administrative Titles

  • Co-Director, Precision Medicine Core, Irving Institute
  • Director, Center for Innovative Exposomics

Credentials & Experience

Education & Training

  • BS, 1989 Old Dominion University
  • MS, 1992 Old Dominion University
  • PhD, 1995 University of Georgia
  • 1997 Emory University
  • 1998 Duke University

Committees, Societies, Councils

NIH All of Us Research Program Advisory Panel

National Advisory Environmental Health Sciences Council (NIEHS Council)

NIH HHEAR Scientific Advisory Board

ATHLETE Exposome Project Scientific Advisory Board, Barcelona, Spain

Editorial Boards

Exposome, Editor-in-Chief (2021-present)

Toxicological Sciences, Editor-in-Chief (2013-2019)

Research

Research Interests

  • Exposomics
  • Neurodegeneration
  • Toxicology

Selected Publications

Books
Miller GW. The Exposome: A New Paradigm for the Environment and Health.  Academic Press, Elsevier, Published June, 2020, 298 pages.

Miller, G.W. The Exposome: A Primer.  Academic Press, Elsevier, New York, 2014. 110 pages

Papers
Bucher ML, Dunn AR, Bradner JM, Egerton KS, Burkett JP, Johnson MA, Miller GW. Synaptic vesicle glycoprotein 2C enhances vesicular storage of dopamine and counters dopaminergic toxicity. Eur J Neurosci. 2024 May;59(10):2483-2501. doi: 10.1111/ejn.16311. Epub 2024 Mar 26.

Kalia V, Kulick ER, Vardarajan B, Gu Y, Manly JJ, Elkind MSV, Kaufman JD, Jones DP, Baccarelli AA, Mayeux R, Kioumourtzoglou MA, Miller GW. Linking Air Pollution Exposure to Blood-Based Metabolic Features in a Community-Based Aging Cohort with and without Dementia. J Alzheimers Dis. 2023;96(3):1025-1040.

Koelmel JP, Xie H, Price EJ, Lin EZ, Manz KE, Stelben P, Paige MK, Papazian S, Okeme J, Jones DP, Barupal D, Bowden JA, Rostkowski P, Pennell KD, Nikiforov V, Wang T, Hu X, Lai Y, Miller GW, Walker DI, Martin JW, Godri Pollitt KJ. An actionable annotation scoring framework for gas chromatography-high-resolution mass spectrometry. Exposome. 2022 Aug 25;2(1):osac007.

Liu KH, Lee CM, Singer G, Bais P, Castellanos F, Woodworth MH, Ziegler TR, Kraft CS, Miller GW, Li S, Go YM, Morgan ET, Jones DP. Large-scale, enzyme-based xenobiotic identification for exposomics. Nature Communications. Sep 14;12(1):5418, 2021.

David A, Chaker J, Price EJ, Bessonneau V, Chetwynd A, Vitale CM, Klanova J, Walker DI, Antignac JP, Barouki R, Miller GW. Towards a comprehensive characterisation of the human internal chemical exposome: challenges and perspectives. Environment International, 2021. Nov;156:106630.

Hu X, Walker DI, Liang Y, Smith MR, Orr ML, Juran BD, Ma C, Uppal K, Koval M, Martin GS, Neujahr DC, Carmen J. Marsit CJ, Go YM, Pennell KD, Miller GW, Lazaridis KN, Jones DP. A scalable workflow for the human exposome. Nature Communications. Sep 22;12(1):5575, 2021.

Vermeulen R, Schymanski E, Barabási AL, Miller GW. The exposome and health: where chemistry meets biology. Science, 367:392-396, 2020.

Dunn AR, Stout KA, Lohr KM, Hoffman C, Bernstein AI, Li Y, Wang M, Sgobio C, Sastry, N, Cai H, Caudle WM, Miller G.W. (2017) Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease. Proceedings of the National Academy of Sciences. Mar 14;114(11):E2253-E2262.PMC5358362. Highlighted in This Week in the Journal.

Lohr KM, Bernstein AI, Stout KA, Dunn AR, Lazo CR, Alter SP, Wang M, Li Y, Fan X, Hess EJ, Yi H, Vecchio LM, Goldstein DS, Guillot TS, Salahpour A, Miller GW. (2014) Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson’s disease-related neurodegeneration in vivo.  Proceedings of the National Academy of Sciences. 111:9977. PMC4103325. *Highlighted in “This Week in PNAS” and also the subject of a feature article in Movement Disorders.

Global Health Activities

SAMBAI: Society, ancestry, molecular, and biological analysis of inequalities. Dr. Miller leads Work Package 2 on exposomics for this Cancer Grand Challenge project that examines cancer health disparities in the African Diaspora (UK, US, Nigeria, Kenya, Ethiopia, Zambia, and South Africa).

EIRENE: European Strategy Forum for Scientific Infrastructures. Dr. Miller leads the Columbia University hub of this European Consortium designed to support the development and harmonization of exposomics.

Visiting Professor, University of Paris Descartes, France: In the Spring of 2018 I was a Visiting Professor at the University of Paris Descartes. I continue to collaborate with colleagues at the University.

EXPANSE Exposome Project, The Netherlands: Funded by the European Commission, this project is studying the effects of complex environmental exposures on human health. Dr. Miller's lab will be assisting with the exposome-level analysis.