MyGoals for Healthy Aging

Research

MyGoals for Healthy Aging has four aims: three data collection/analysis aims through the fifth study year and a fourth aim to enable longer-term investigations via state-of-the-art data linking and biobanking methodologies.

  • Aim 1) To test the hypothesis that the intervention improves economic and behavioral pathways that may influence the risk of aging and future AD/ADRD. Economic wellbeing (employment, income, housing, crime, health insurance) and health behavior (diet and exercise) will be measured from administrative records and validated survey instruments and compared between intervention and control groups.
  • Aim 2) To test the hypothesis that the intervention improves mental-health, physical health, and cognitive pathways to aging and AD/ADRD. Mental and physical health (sleep, loneliness, psychological stress, depression, obesity, health-related quality of life, C-reactive protein, and HbA1C) and executive function will be measured from validated survey instruments and laboratory assays of blood samples and compared between intervention and controls groups.
  • Aim 3) To test the hypothesis that the intervention slowed aging-related biological changes contributing to risk for AD/ADRD. We will measure aging-related biological changes from whole-genome DNA methylation data derived from blood samples using Illumina EPIC arrays. We will use validated algorithms to quantify the pace of biological aging (DunedinPoAm) and biological age (GrimAge clock). Analysis will compare DunedinPoAm pace of aging and Grim Age between treatment and control groups.
  • Aim 4) To enable longer-term outcome assessments via cutting-edge data linkages and biobanking. We will curate data into a shareable resource with administrative outcomes added on an ongoing basis.

 

Please stay tuned for more information.

  • This page will list the pre-specifications of the statistical models used in the planned analyses once the package has been finalized. See current information on MyGoals for Healthy Aging statisitical design and power.
  • This page will also contain public use data and information on how researchers can access biospecimens for future analyses.

When will the public use dataset be made available?

The availability of a public use dataset is contingent on funding. We will update information as our funding status is known.