Randolph Reyes Singh, PhD

Randolph Singh is an Assistant Professor in the Department of Environmental Health Sciences at Columbia Mailman School of Public Health. His primary focus lies at the intersection of human health, environmental health, and analytical chemistry.

Randolph employs high-resolution mass spectrometry (HRMS)-based nontarget analysis (NTA) to tackle questions in the field like:

• How can we harness the power of HRMS and complementary techniques to navigate the largely uncharted chemical landscape that constitutes the exposome, particularly in extensive human disease cohorts such as Alzheimer's disease and other neurodegenerative conditions?
• What discernible disparities exist in the chemical profiles of individuals afflicted with illness compared to those in robust health?
• Can the disparities in chemical profiles, particularly those associated with contaminant exposure, provide insights into the causation of disease endpoints, or can we delve deeper into understanding how these chemical exposures trigger toxic effects at the metabolome and lipidome levels, contributing to the development and progression of diseases?

To address these multifaceted challenges, Randolph combines the disciplines of analytical chemistry and environmental cheminformatics in collaboration with other public health scientists. He addresses these challenges by leveraging analytical chemistry and environmental cheminformatics to identify organic contaminants in various matrices particularly human biospecimens. His current research endeavors benefit from his extensive experience in working with complex matrices such as wastewater and biota. In these environments, Randolph has probed the presence of various chemical classes, including antimicrobials, pharmaceuticals, personal care products (PPCPs), as well as persistent organic pollutants like OCPs, PAHs, PBDEs, PCBs, and PFAS.

Office Location: 630 West 168th Street, VP&S Room 16-410