Randolph Reyes Singh, PhD

  • Assistant Professor of Environmental Health Sciences
Profile Headshot


Randolph Singh is an Assistant Professor in the Department of Environmental Health Sciences at Columbia Mailman School of Public Health. His primary focus lies at the intersection of human health, environmental health, and analytical chemistry.

Randolph employs high-resolution mass spectrometry (HRMS)-based nontarget analysis (NTA) to tackle questions in the field like:

  • How can we harness the power of HRMS and complementary techniques to navigate the largely uncharted chemical landscape that constitutes the exposome, particularly in extensive human disease cohorts such as Alzheimer's disease and other neurodegenerative conditions?
  • What discernible disparities exist in the chemical profiles of individuals afflicted with illness compared to those in robust health?
  • Can the disparities in chemical profiles, particularly those associated with contaminant exposure, provide insights into the causation of disease endpoints, or can we delve deeper into understanding how these chemical exposures trigger toxic effects at the metabolome and lipidome levels, contributing to the development and progression of diseases?

To address these multifaceted challenges, Randolph combines the disciplines of analytical chemistry and environmental cheminformatics in collaboration with other public health scientists. He addresses these challenges by leveraging analytical chemistry and environmental cheminformatics to identify organic contaminants in various matrices particularly human biospecimens. His current research endeavors benefit from his extensive experience in working with complex matrices such as wastewater and biota. In these environments, Randolph has probed the presence of various chemical classes, including antimicrobials, pharmaceuticals, personal care products (PPCPs), as well as persistent organic pollutants like OCPs, PAHs, PBDEs, PCBs, and PFAS.

Office Location: 630 West 168th Street, VP&S Room 16-410

Academic Appointments

  • Assistant Professor of Environmental Health Sciences

Administrative Titles

  • Deputy Director, Center for Innovative Exposomics

Credentials & Experience

Education & Training

  • BSc, 2008 University of the Philippines Diliman
  • PhD, 2017 The State University of New York at Buffalo


Research Interests

  • Chemical Exposome
  • Environmental Epidemiology
  • Environmental Health
  • HRMS-based Nontarget Analysis

Selected Publications

Singh RR, Aminot Y, Héas-Moisan K, Preud'homme H, Munschy C. Cracked and shucked: GC-APCI-IMS-HRMS facilitates identification of unknown halogenated organic chemicals in French marine bivalves. Environ Int. 2023 Aug;178:108094. doi: 10.1016/j.envint.2023.108094. Epub 2023 Jul 13. PubMed PMID: 37478678.

Singh RR, Lai A, Krier J, Kondi? T, Diderich P, Schymanski EL. Occurrence and Distribution of Pharmaceuticals and Their Transformation Products in Luxembourgish Surface Waters. ACS Environ Au. 2021 Nov 17;1(1):58-70. doi: 10.1021/acsenvironau.1c00008. eCollection 2021 Nov 17. PubMed PMID: 37101936; PubMed Central PMCID: PMC10114791.

Angeles LF, Singh RR, Vikesland PJ, Aga DS. Increased coverage and high confidence in suspect screening of emerging contaminants in global environmental samples. J Hazard Mater. 2021 Jul 15;414:125369. doi: 10.1016/j.jhazmat.2021.125369. Epub 2021 Feb 11. PubMed PMID: 33647625.

Singh RR, Chao A, Phillips KA, Xia XR, Shea D, Sobus JR, Schymanski EL, Ulrich EM. Expanded coverage of non-targeted LC-HRMS using atmospheric pressure chemical ionization: a case study with ENTACT mixtures. Anal Bioanal Chem. 2020 Aug;412(20):4931-4939. doi: 10.1007/s00216-020-02716-3. Epub 2020 Jun 3. PubMed PMID: 32494915; PubMed Central PMCID: PMC7477815.

Singh RR, Lester Y, Linden KG, Love NG, Atilla-Gokcumen GE, Aga DS. Application of metabolite profiling tools and time-of-flight mass spectrometry in the identification of transformation products of iopromide and iopamidol during advanced oxidation. Environ Sci Technol. 2015 Mar 3;49(5):2983-90. doi: 10.1021/es505469h. Epub 2015 Feb 17. PubMed PMID: 25651339.

See a complete list of publications.