Hui-Chen Wu, DrPH

  • Assistant Professor of Environmental Health Sciences CUMC
Profile Headshot


Dr. Wu's research involves examining the relationship between DNA methylation markers and risk of hepatocellular carcinoma  as well as breast cancer and understanding risk factors that may modulate the DNA methylation changes.

Dr. Wu also directs a biomarker core laboratory that processes and stores of biospecimens for clinical trials conducted within Columbia's Herbert Irving Comprehensive Cancer Cancer.

Office Location: 630 West 168th Street, VP&S Room 16-421E

Academic Appointments

  • Assistant Professor of Environmental Health Sciences CUMC

Credentials & Experience

Education & Training

  • DrPH, 2007 Columbia University Mailman School of Public Health


Selected Publications

1. Hui-Chen Wu, Hwai-I Yagn, Qiao Wang, Chien-Jen Chen, Regina M. Santella (2017). Plasma DNA Methylation Marker and Hepatocellular Carcinoma Risk Prediction Model for the General Population. Carcinogenesis. 38: 1021-1028. PMID: 28981677; PMCID: PMC582336

2. Hui-Chen Wu, Laura A. Brennan, Mandy Goldberg, Wendy K. Chung, Irene L. Andrulis, Angela R. Bradbuty, Easter M. John, Mary B Daly, Sundra S Buys, Regina M. Santella, Mary Beth Terry (2020). Influence of Puberty Department on Urinary Oxidative Stress Biomarkers in Adolescent Girls in the New York LEGACY Cohort. Free Radical Research.54:431-441; PMID: 32686531; PMCID:PMC7731215

3. Hui-Chen Wu, Jing Shen, Abby Siegel, Regina Santella. (2021) Environmental Exposure and clinical correlates of hepatocellular carcinoma in New York City: A case only study. Cancer Cause & Control. PMID:34498221; PMCID:PMC8786455

4. Maya Spaur, Anne E Nigra, Tiffany R Sanchez, Ana Navas-Acien, Mariana Lazo Lizondo, Hui-Chen Wu (2022). Association of blood Manganese with subclinical measures of liver disease in NHANES 2017-2018. Environmental Research. PMID:35691383

5. Hui-Chen Wu, Wen-Juei Jeng, Mei-Hung Pan, Yi-Chung Hsieh, Sheng-Nan Lu, Chien-Jen Chen, Hwai-I Yang (2022). Incidence of hepatocellular carcinoma in a community-based Taiwanese population without chronic hepatitis B/C virus infection. JHEP Reports. PMID:35079699; PMCID:PMC8777288

6. Hui-Chen Wu, Rebecca Kehm, Regina Santella, David J Brenner, Mary Beth Terry (2022). DNA damage and repair and Cancer Risk: a systematic review and meta-analysis of 55 case-control studies. Scientific Reports. PMCID:PMC8888613.PMID35233009