Zachary Lawrence Mannes, PhD, MPH

  • Assistant Professor of Epidemiology (in Emergency Medicine)

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Overview

Dr. Zachary Mannes is an Assistant Professor of Epidemiology in Emergency Medicine at Columbia University. He received his MPH and PhD from the University of Florida’s College of Public Health and Health Professions and trained as a predoctoral clinical psychology intern at the Yale School of Medicine. Following his graduate training, Dr. Mannes completed a National Institutes of Health–funded postdoctoral fellowship in substance use disorder epidemiology at Columbia University.

As a licensed clinical psychologist and epidemiologist, Dr. Mannes’ research leverages data from national surveys and electronic health records to examine the impact of clinical and public health interventions on opioid-related health outcomes. The long-term goal of his work is to inform clinical care, identify gaps in healthcare delivery, and promote the uptake of safe and effective behavioral treatments to reduce the burden of opioid use disorder and fatal and nonfatal opioid overdose. His research is supported by the National Institute on Drug Abuse and National Center for Complementary and Integrative Health.

Academic Appointments

  • Assistant Professor of Epidemiology (in Emergency Medicine)

Administrative Titles

  • Training Coordinator, Substance Abuse Epidemiology Training Program

Gender

  • Male

Credentials & Experience

Education & Training

  • BS, Virginia Tech
  • MPH, University of Florida
  • PhD, University of Florida
  • Fellowship: Clinical, Yale University
  • Fellowship: Postdoctoral Research, Columbia University

Research

Research Interests

  • Chronic Pain
  • Mental Health
  • Substance Use
  • Veteran Health

Selected Publications

Mannes ZL, Wall MM, Alschuler DM, Malte CA, Olfson M, Livne O, Fink DS, Keyhani S, Keyes KM, Martins SS, Cerdá M, Sacco DL, Gutkind S, Maynard CC, Sherman S, Saxon AJ, Hasin DS. Cannabis Legalization and Opioid Use Disorder in Veterans Health Administration Patients. JAMA Health Forum. 2025 Jun 7;6(6):e251369. doi: 10.1001/jamahealthforum.2025.1369. PMCID: PMC12166489.

Mannes ZL, Nowels M, Mauro C, Cook S, Wheeler-Martin K, Gutkind S, Bruzelius E, Doonan SM, Crystal S, Davis CS, Samples H, Hasin DS, Keyes KM, Rudolph KE, Cerdá M, Martins SS. The Combined Relationship of Prescription Drug Monitoring Program Enactment and Medical Cannabis Laws with Chronic Pain-Related Healthcare Visits. J Gen Intern Med. 2025 Apr;40(5):1030-1038. doi: 10.1007/s11606-024-09053-6. PMCID: PMC11968579.

Mannes ZL, Malte CA, Olfson M, Wall MM, Keyes KM, Martins SS, Cerdá M, Gradus JL, Saxon AJ, Keyhani S, Maynard C, Livne O, Fink DS, Gutkind S, Hasin DS. Increasing Risk of Cannabis Use Disorder among U.S. veterans with Chronic Pain: 2005-2019. Pain. 2023 Sep 1;164(9):2093-2103. doi: 10.1097/j.pain.0000000000002920. PMCID: PMC10524371.


Mannes, ZL, Stohl M, Fink DS, Olfson M, Keyes KM, Martins SS, Gradus JL, Saxon AJ, Maynard C, Livne O, Gutkind S, & Hasin DS. Non-pharmacological Treatment for Chronic Pain in US Veterans Treated within the Veterans Health Administration: Implications for Expansion in US Healthcare Systems. Journal of General Internal Medicine. 2022. doi: 10.1007/s11606-021-07370-8. PMCID: PMC8769678

Mannes ZL, Dunne EM, Ferguson EG, Cottler LB, Ennis N. History of Opioid Use as a Risk Factor for Current Use and Mental Health Consequences among Retired National Football League Athletes: A 9-year follow-up Investigation. Drug Alcohol Depend. 2020 Oct 1;215:108251. doi: 10.1016/j.drugalcdep.2020.108251. PMCID: PMC7590231.

For a complete list of publications, please visit PubMed.gov