Kupsco Lab on Environmental Epigenetics and Children's Health

Publications

Current through Summer 2024. A full list of the lab’s published work is available below.

Full List of Publications
  1. Bloomquist TR; Spaur M; Cerna-Turoff I; Kress AM; Burjak M; Kupsco A; Casey JA; Herbstman JB; Nigra AE. Public drinking water contaminant estimates for birth cohorts in the Environmental Influences on Child Health Outcomes (ECHO) Cohorts. Journal Of Exposure Science And Environmental Epidemiology (In Press)
  2. Reddam A; Bloomquist TR; Covell LT; Hu H; Oberfield SE; Gallagher D; Goldsmith J, Rundle AG; Baccarelli AA; Herbstman JB; Kupsco A*. Inverse Associations of Cord Blood Mitochondrial DNA Copy Number with Childhood Adiposity. Obesity. 2024. (In Press)
  3. Jiang EX; Domingo-Relloso A; Abuawad A; Haack K; Tellez-Plaza M; Fallin MD; Umans JG; Best LG; Zhang Y; Kupsco A; Belsky DW; Cole SA, Navas-Acien A. Arsenic Exposure and Accelerated Aging: The Association with Cardiovascular Disease and All-Cause Mortality in the Strong Heart Study. Environ Health Perspect. 2023 Dec;131(12):127016. PMCID: PMC10743589
  4. Lieberman-Cribbin W; Li Z; Lewin M; Ruiz P; Jarrett J; Cole S; Kupsco A; O'Leary M; Pichler G; Shimbo D; Devereux R; Umans J; Navas-Acien A; Nigra A. The Contribution of Declines in Blood Lead Levels to Reductions in Blood Pressure Levels: Longitudinal Evidence in the Strong Heart Family Study. JAHA. In press
  5. Boyer K, Domingo-Relloso A, Jiang E, Haack K, Goessler W, Zhang Y, Umans JG, Belsky DW, Cole S, Navas-Acien A, Kupsco A*. Metal Mixtures and DNA Methylation Measures of Biological Aging in American Indian Populations. Environment International. 2023, 178: 108064. PMCID: PMC10617409
  6. Holzhausen EA, Kupsco A, Chalifour B, Patterson WB, Schmidt KA, Mokhtari P, Baccarelli AA, Goran M, Alderete TL. Influence of technical and maternal-infant factors on the measurement and expression of extracellular miRNA in human milk. Frontiers in Immunology. 2023;14:1151870. PMCID: PMC10363855
  7. Holzhausen EA, Kupsco A, Chalifour B, Patterson WB, Schmidt KA, Mokhtari P, Baccarelli AA, Goran M, Alderete TL. Human Milk EV-miRNAs: A Novel Biomarker for Air Pollution Exposure During Pregnancy. Environmental Research: Health. 2023 Sep 1;1(3):035002. PMCID: PMC10486183
  8. Kupsco A, Bloomquist TR; Hu H; Reddam AR; Tang D; Goldsmith AG; Rundle AG ; Baccarelli AB; Herbstman JB. Mitochondrial DNA copy number dynamics and associations with the prenatal environment from birth through adolescence in a population of Dominican and African American children. Mitochondrion. 2023 Mar;69:140-146. PMCID: PMC10006332
  9. Diddier Prada D, Crandall CG, Kupsco A, Kioumourtzoglou M-A, Stewart JD, Liao D, Yanosky J, Ramirez A, Wactawski-Wende J, Shen Y, Miller G, Ionita-Laza I, Whitsel EA, Baccarelli AA. Air Pollution and Decreased Bone Mineral Density Among Women's Health Initiative Participants. EClinicalMedicine. 2023 Feb 15;57:101864. PMCID: PMC9938170
  10. Dye CK, Domingo-Relloso A, Kupsco A, Tinkleman N, Spratlen MJ, Bozack A, Tellez-Plaza M, Grau-Perez M, Goessler W, MacCluer J,  Haack K, Umans J, Cole S, Baccarelli AA, Navas-Acien A. Maternal DNA Methylation Signatures of Arsenic Exposure is Associated with Adult Offspring Insulin Resistance in the Strong Heart Study. Environment International. 2023 Mar;173:107774.  PMCID: PMC10166110
  11. Reddam A, Sjödin A; Cowell W; Jones R; Wang S; Perera FP; Herbstman JB; Kupsco A*. Prenatal Exposure to Polybrominated Diphenyl Ethers and Birth Outcomes. Environmental Research. 2023 Jan 1;216(Pt 4):114830. PMCID: PMC9729424
  12. Lieberman-Cribbin W, Domingo-Relloso A, Navas-Acien A, Cole S, Haack K, Umans J, Tellez-Plaza M, Colicino E, Baccarelli AA, Gao X, Kupsco A*. Epigenetic biomarkers of lead exposure and cardiovascular disease: prospective evidence in the Strong Heart Study. J Am Heart Assoc. 2022 Dec 6;11(23):e026934. PMCID: PMC9851430
  13. Kupsco A, Sjödin A, Cowell W, Jones R, Oberfield S, Wang S, Hoepner LA, Gallagher D, Baccarelli AA, Goldsmith J, Rundle AG, Herbstman JB. Prenatal exposure to polybrominated diphenyl ethers and BMI Z-scores from 5 to 14 years. Environ Health. 2022 Sep 8;21(1):82. PMCID: PMC9454187.
  14. Deierlein AL, Wu H, Just AC, Kupsco A, Braun JM, Oken E, Soria-Contreras DC, Cantoral A, Pizano ML, McRae N, Téllez-Rojo MM, Wright RO, Baccarelli AA. Prenatal phthalates, gestational weight gain, and long-term weight changes among Mexican women. Environ Res. 2022 Jun 1;209:112835. PMCID: PMC8976769
  15. Kupsco A; Prada D; Valvi D; Hu L; Skaalum Peterson M; Coull B; Grandjean P; Weihe P; Baccarelli AA. Marine pollutant exposures and human milk extracellular vesicle-microRNAs in a mother-infant cohort from the Faroe Islands. Environ Int. 2022 Jan;158:106986. PMCID: PMC8742869
  16. Wu H; Kupsco A; Just,AC; Calafat AM; Oken E; Braun J; Sanders AP; Mercado-Garcia A; Cantoral A; Pantic I; Téllez- Rojo MM; Wright RO; Baccarelli AA; Deierlin A. Maternal Phthalates Exposure and Blood Pressure During and After Pregnancy in the PROGRESS Study. Environ Health Perspect. 2021 Dec;129(12):127007. PMCID: PMC8693773
  17. Kupsco A; Wu H; Calafat AM; Kioumourtzoglou M-A; Cantoral A; Tamayo-Ortiz M; Pantic I; Pizano-Zarate, ML; Oken E; Braun J; Deierlein A; Wright RO; Téllez- Rojo MM; Baccarelli AA; Just AC. Prenatal Maternal Phthalate Exposures and Trajectories of Childhood Adiposity from Four to Twelve Years. Environ Res. Sept 2021 PMID: 34563522
  18. Kupsco A; Prada D; Valvi D; Hu L; Skaalum Peterson M; Coull B; Grandjean P; Weihe P; Baccarelli AA. Breast milk extracellular vesicle miRNAs, pathways, and ontology in a population-based mother-infant cohort from the Faroe Islands. Sci Rep. 2021; 11: 5840. PMCID: PMC7970999
  19. Ronkainen J, Heiskala A, Vehmeijer FOL, Lowry E, Caramaschi D, Gutiérrez GE, Heiss JA, Hummel N, Keikkala E, Kvist T, Kupsco A, Melton PE, Pesce G, Soomro MH, Vives-Usano M, Baiz N, Binder E, Czamara D, Guxens M, Mustaniemi S, London SJ, Rauschert S, Vääräsmäki M, Vrijheid M, Ziegler A-G, Annesi-Maesano I, Bustamante M, Huang R-C, Hummel S, Just AC, Kajantie E, Lahti J, Lawlor D, Räikkönen K, Järvelin M-R, Felix JF, Sebert S. Maternal haemoglobin levels in pregnancy and child DNA methylation: a study in the Pregnancy And Childhood Epigenetics Consortium. Epigenetics. Taylor & Francis; 2022 Jan;17(1):19-31. PMCID: PMC8813068
  20. Kupsco A; Wu H; Calafat AM; Kioumourtzoglou M-A; Tolentino M; Oken E; Braun J; Mercado-Garcia A; Wright RO; Téllez- Rojo MM; Baccarelli AA; Just AC. Prenatal Maternal Phthalate Exposures and Child Lipid and Adipokine Levels at Age 6: A Study from the PROGRESS Cohort of Mexico City. Environ Res. 2021 Jan;192:110341. PMCID: PMC7736226.
  21. Kupsco A; Gonzalez G; Baker BH; Knox JM; Zheng Y; Wang S; Chang D; Schwartz J; Hou L; Wang Y; Baccarelli AA. Associations of Smoking and Air Pollution with Peripheral Blood RNA N6-methyladenosine in the Beijing Truck Driver Air Pollution Study. Environ. Int. 2020 Nov;144:106021. PMCID: PMC7572654
  22. Haotian W; Kupsco A; Deierlin A; Just,AC; Calafat AM; Oken E; Braun J; Mercado-Garcia A; Cantoral A; Téllez- Rojo MM; Wright RO; Baccarelli AA. Trends and Patterns of Phthalates and Phthalate Alternatives Exposure in Pregnant Women from Mexico City during 2007-2010. Environ. Sci. Technol. 2020; 54 (3): 1740–1749. PMCID: PMC7094762
  23. Kupsco, A; Estrada-Gutierrez, G; Cantoral, A; Schnaas, L; Pantic, I; Amarasiriwardena, C; Svensson, K; Bellinger, DC; Téllez-Rojo, MM; Baccarelli, AA; Wright, RO. Modification of the effects of prenatal manganese exposure on child neurodevelopment by maternal anemia and iron deficiency. Ped. Res. 2020. 88: 325–333. PMCID: PMC7351595
  24. Kupsco A, Sanchez-Guerra M, Amarasiriwardena C, Brennan KJM, Estrada-Gutierrez G, Svensson K, Schnaas L, Pantic I, Téllez-Rojo MM, Baccarelli AA, Wright RO. Prenatal manganese and cord blood mitochondrial DNA copy number: Effect modification by maternal anemic status. Environ Int. 2019 May;126:484–493. PMCID: 6471611
  25. Kupsco A, Kioumourtzoglou M-A, Just AC, Amarasiriwardena C, Estrada-Gutierrez G, Cantoral A, Sanders AP, Braun JM, Svensson K, Brennan KJ, Oken E, Wright RO, Baccarelli AA, Téllez-Rojo MM. Prenatal metal concentrations and childhood cardio-metabolic risk using Bayesian Kernel Machine Regression to assess mixture and interaction effects. Epidemiology. 2018 Nov 30; PMCID: 6402346
  26. Amiri BM, Xu EG, Kupsco A, Giroux M, Hoseinzadeh M, Schlenk D. The effect of chlorpyrifos on salinity acclimation of juvenile rainbow trout (Oncorhynchus mykiss). Aquat Toxicol. 2018 Feb;195:97–102. PMID: 29304407
  27. Yamamoto FY, Garcia JRE, Kupsco A, Oliveira Ribeiro CA. Vitellogenin levels and others biomarkers show evidences of endocrine disruption in fish species from Iguaçu River - Southern Brazil. Chemosphere. 2017 Nov;186:88–99. PMID: 28772185
  28. Pflug NC, Kupsco A, Kolodziej EP, Schlenk D, Teesch LM, Gloer JB, Cwiertny DM. Formation of bioactive transformation products during glucocorticoid chlorination. Environ Sci: Water Res Technol. 2017 May 5;3(3):450–461.
  29. Kupsco A, Sikder R, Schlenk D. Comparative Developmental Toxicity of Desalination Brine and Sulfate-Dominated Saltwater in a Euryhaline Fish. Arch Environ Contam Toxicol. 2017 Feb;72(2):294–302. PMID: 28054105
  30. Kupsco A, Schlenk D. Developmental expression and regulation of flavin-containing monooxygenase by the unfolded protein response in Japanese medaka (Oryzias latipes). Comp Biochem Physiol C Toxicol Pharmacol. 2017 Jan;191:7–13. PMID: 27612667
  31. Kupsco A, Dasgupta S, Nguyen C, Volz DC. Dynamic Alterations in DNA Methylation Precede Tris(1,3-dichloro-2-propyl)phosphate-Induced Delays in Zebrafish Epiboly. Environ Sci Technol Lett. 2017 Sep 12;4(9):367–373. PMCID: PMC5630170
  32. Dasgupta S, Vliet SM, Kupsco A, Leet JK, Altomare D, Volz DC. Tris(1,3-dichloro-2-propyl) phosphate disrupts dorsoventral patterning in zebrafish embryos. PeerJ. 2017;5:e4156. PMCID: PMC5733366
  33. Kupsco A, Schlenk D. Stage susceptibility of Japanese medaka (Oryzias latipes) to selenomethionine and hypersaline developmental toxicity. Environ Toxicol Chem. 2016 May;35(5):1247–1256. PMCID: PMC5425095
  34. Kupsco A, Schlenk D. Molecular mechanisms of selenium-Induced spinal deformities in fish. Aquat Toxicol. 2016 Oct;179:143–150. PMID: 27611865
  35. Freitas JS, Kupsco A, Diamante G, Felicio AA, Almeida EA, Schlenk D. Influence of Temperature on the Thyroidogenic Effects of Diuron and Its Metabolite 3,4-DCA in Tadpoles of the American Bullfrog (Lithobates catesbeianus). Environ Sci Technol. 2016 06;50(23):13095–13104. PMID: 27787998
  36. Crago J, Xu EG, Kupsco A, Jia F, Mehinto AC, Lao W, Maruya KA, Gan J, Schlenk D. Trophic transfer and effects of DDT in male hornyhead turbot (Pleuronichthys verticalis) from Palos Verdes Superfund site, CA (USA) and comparisons to field monitoring. Environ Pollut. 2016 Jun;213:940–948. PMCID: PMC4879599
  37. Kupsco A, Schlenk D. Mechanisms of selenomethionine developmental toxicity and the impacts of combined hypersaline conditions on Japanese medaka (Oryzias latipes). Environ Sci Technol. 2014 Jun 17;48(12):7062–7068. PMCID: PMC4066905

Reviews, Book Chapters, and Commentaries

  1. Prada DP, Baccarelli AA, Kupsco A, Parks R. Cellular and Molecular Mechanisms of Health Damage and Preventive Strategies for Climate Change-related Health Outcomes. Nature Medicine (In Press)
  2. Gaylord A, Cohen AA, Kupsco A*, Biomarkers of aging through the life course: A Recent Literature Update. Current opinion in epidemiology and public health. 2023, 2(2): 7-17. PMCID: PMC10732539.
  3. Reddam A, McLarnan S, Kupsco A*. Environmental Chemical Exposures and Mitochondrial Dysfunction: A Review of Recent Literature. Curr Environ Health Rep. 2022 Dec;9(4):631-649. PMCID: PMC9729331.
  4. Kupsco A, Schlenk D. Oxidative stress, unfolded protein response, and apoptosis in developmental toxicity. Int Rev Cell Mol Biol. 2015;317:1–66. PMCID: PMC4792257