Cohen Lab on Aging, Systems and Statistics

Publications

Selected Publications

  1. Franck, M., Tanner, K., Tennyson, R.L., …, and Cohen, A.A.* (2025). Nonuniversality of inflammaging across human populations. Nature Aging, 1-10. 10.1038/s43587-025-00888-0
  2. Cohen, A.A., Picard, M., Beard, J.R., Belsky, D.W., Herbstman, J., Kuryla, C.L., Liu, M., Makarem, N., Malinsky, D., Pei, S., Wei, Y., and Fried, L.P. (2025) Intrinsic Health as a Foundation for a Science of Health. Science Advances. 11 eadu8437. 10.1126/sciadv.adu8437
  3. Senior, A.M., Legault, V., Lavoie, F.B., Presse, N., Gaudreau, P., Turcot, V., Raubenheimer, D., Le Couteur, D.G., Simpson, S.J., Cohen, A.A. (2022). Multidimensional associations between nutrient intake and healthy ageing in humans. BMC Biology, 20(1): 196. https://doi.org/10.1186/s12915-022-01395-z
  4. Cohen, A.A., Ferrucci, L., Fülöp, T., Gravel, D., Hao, N., Kriete, A., Levine, M.E., Lipsitz, L.A., Olde Rikkert, M.G.M., Rutenberg, A., Stroustrup, N., Varadhan, R. (2022). A Complex Systems Approach to Aging Biology. Nature Aging, 2, 580–591. https://doi.org/10.1038/s43587-022-00252-6
  5. Cohen, A.A., Leung, D.L., Legault, V., Gravel, D., Blanchet, F.G., Côté, A.M., Fulop, T., Lee, J., Dufour, F., Liu, M., Nakazato, Y. (2022). Synchrony of biomarker variability indicates a critical transition: Application to mortality prediction in hemodialysis. iScience, 25(6): 104385. https://doi.org/10.1016/j.isci.2022.104385
  6. Wensink, M.J., Cohen, A.A*. (2022). The Danaid Theory of Aging. Frontiers in Cell and Developmental Biology, 9:671208. https://doi.org/10.3389/fcell.2021.671208. *Both authors contributed equally to this work.
  7. Cohen, A.A., Leblanc, S., Roucou, X. (2021). Robust physiological metrics from sparsely sampled networks. Front. Physiol, 12:624097. https://doi.org/10.3389/fphys.2021.624097
  8. Cohen, A.A., Legault, V., Fulop, T. (2020). What if there’s no such thing as “aging”? Mechanisms of Ageing and Development, 192:111344. https://doi.org/10.1016/j.mad.2020.111344
  9. Cohen, A.A., Kennedy, BK., Anglas, U., Bronikowski, AM., Deelen, J., Dufour, F., Ferbeyre, G., Ferrucci, L., Franceschi, C., Frasca, D., Friguet, B., Gaudreau, P., Gladyshev VN., Gonos, ES., Gorbunova, V., Gut, P., Ivancheko, M., Legault, V., Lemaître, J-F., Liontis, T., Liu, G-H., Liu, M., Maier, AB., Nobrega, OT., Rikkert, M., Pawelec, G., Rheault, S., Senior, AM., Simm, A., Soo, S., Traa, A., Ukraintseva, S., Vanhaelen, Q., Raamsdonk, J., Witkowski, J., Yashin, A., Ziman, R., Fulop, T. (2020). Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mechanisms of Ageing and Development, 191:111316. https://doi.org/10.1016/j.mad.2020.111316
  10. Cohen, A.A., Levasseur M, Raina P, Fried LP, Fülöp T. (2020). Is aging biology ageist? Journal of Gerontology: Biological Sciences, 75(9): 1653-1655. https://doi.org/10.1093/gerona/glz190
  11. Cohen, A.A., Coste, C., Li, X-Y, Bourg, S., and Pavard, S. (2020). Are trade-offs really the key drivers of aging and lifespan? Functional Ecology, 34(1):153–166. https://doi.org/10.1111/1365-2435.13444
  12.  Dansereau, G., Wey, T.W., Legault, V., Brunet, M.A., Kemnitz, J.W., Ferrucci, L., Cohen, A.A. (2019). Conservation of physiological dysregulation signatures of aging across primates. Aging Cell, 18(2): e12925. https://doi.org/10.1111/acel.12925
  13. Cohen, A.A., Legault, V., Fuellen, G., Fulop, T., Fried, L.P., Ferrucci, L. (2018). The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations. Experimental Gerontology, 107: 11-17. https://doi.org/10.1016/j.exger.2017.07.011
  14. Cohen, A.A., Isaksson, C., Salguero-Gómez, R. (2017). Co-existence of multiple trade-off currencies has major impacts on evolutionary outcomes. PLOS ONE, 12(12):e0189124. https://doi.org/10.1371/journal.pone.0189124
  15. Cohen, A.A. (2017). Aging across the tree of life: the importance of a comparative perspective for the use of animal models in aging. BBA - Molecular Basis of Disease, 1864:2680-2689. https://doi.org/10.1016/j.bbadis.2017.05.028
  16. Cohen, A.A. (2016). Complex systems dynamics in aging: new evidence, continuing questions. Biogerontology, 17(1):205-20. https://doi.org/10.1007/s10522-015-9584-x
  17. Li, Q., Wang, S., Milot, E., Bergeron, P., Ferrucci, Fried, L.P., Cohen, A.A. (2015). Homeostatic dysregulation proceeds in parallel in multiple physiological systems. Aging Cell, 14(6):1103-12. https://doi.org/10.1111/acel.12402
  18. Cohen, A.A., Milot, E., Li, Q., Bergeron, P., Poirier, R., Dusseault-Bélanger, F., Fulop, T., Leroux, M., Legault, V., Metter, E.J., Fried, L.P., Ferrucci, L. (2015). Detection of a novel, integrative aging process suggests complex physiological integration. PLoS ONE, 10(3): e0116489. https://doi.org/10.1371/journal.pone.0116489
  19. Barnwell-Ménard, JL., Li, Q., and Cohen, A.A. (2015). Effects of categorization method, regression type, and variable distribution on the inflation of Type-I error rate when categorizing a confounding variable. Statistics in Medicine, 34(6): 936-949. https://doi.org/10.1002/sim.6387
  20. Milot, E., Cohen, A.A., Vézina, F., Buehler, D. M., Matson, K. D. & Piersma, T. (2014). A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation. Methods in Ecology and Evolution, 5: 146-155. https://doi.org/10.1111/2041-210X.12145
  21. Morrisette-Thomas, V., Cohen, A.A., Fulop, T., Riesco, E., Legault, V., Li, Q., Milot, E., Dusseault-Bélanger, F., Ferrucci, L. (2014). Inflammaging does not simply reflect increases in pro‐inflammatory markers. Mechanisms of Ageing and Development, 139: 49-57. https://doi.org/10.1016/j.mad.2014.06.005
  22. Cohen, A.A., Milot, E., Li Q., Legault, V., Fried, L.P., Ferrucci, L. (2014). Cross-population validation of statistical distance as a measure of physiological dysregulation during aging. Experimental Gerontology, 57; 203-210. https://doi.org/10.1016/j.exger.2014.04.016
  23. Cohen, A.A., Milot, E., Yong, J., Seplaki, C.L., Fulop, T., Bandeen-Roche, K. & Fried, L. P. (2013). A Novel Statistical Approach Shows Evidence for Multi-system Physiological Dysregulation During Aging. Mechanisms of Ageing and Development, 134(3-4):110-7. https://doi.org/10.1016/j.mad.2013.01.004
  24. Cohen, A.A., Martin, L.B., Wingfield, J.C., McWilliams, S.R. (2012). Physiological Regulatory Networks: Ecological Roles and Evolutionary Constraints. Trends in Ecology and Evolution 27 (8): 428-435. https://doi.org/10.1016/j.tree.2012.04.008
  25. Cohen, A.A., McGraw, K.J., Wiersma, P., Williams, J.B., Robinson, W.D., Robinson, T.R., Brawn, J.D., and Ricklefs, R.E. (2008). Interspecific Associations Between Circulating Antioxidant Levels and Life History Variation in Birds. The American Naturalist 172(2): 178-193. https://doi.org/10.1086/589456
  26. Cohen, A.A. (2004). Female Post-Reproductive Lifespan: A General Mammalian Trait. Biological Reviews, 79: 733-750. https://doi.org/10.1017/s1464793103006432

 

PubMed Bibliography