Cohen Lab on Aging, Systems and Statistics

Publications

Selected Publications

  1. Senior, A.M., Legault, V., Lavoie, F.B., Presse, N., Gaudreau, P., Turcot, V., Raubenheimer, D., Le Couteur, D.G., Simpson, S.J., Cohen, A.A. (2022). Multidimensional associations between nutrient intake and healthy ageing in humans. BMC Biology, 20(1): 196. https://doi.org/10.1186/s12915-022-01395-z
  2. Cohen, A.A., Ferrucci, L., Fülöp, T., Gravel, D., Hao, N., Kriete, A., Levine, M.E., Lipsitz, L.A., Olde Rikkert, M.G.M., Rutenberg, A., Stroustrup, N., Varadhan, R. (2022). A Complex Systems Approach to Aging Biology. Nature Aging, 2, 580–591. https://doi.org/10.1038/s43587-022-00252-6
  3. Cohen, A.A., Leung, D.L., Legault, V., Gravel, D., Blanchet, F.G., Côté, A.M., Fulop, T., Lee, J., Dufour, F., Liu, M., Nakazato, Y. (2022). Synchrony of biomarker variability indicates a critical transition: Application to mortality prediction in hemodialysis. iScience, 25(6): 104385. https://doi.org/10.1016/j.isci.2022.104385
  4. Wensink, M.J., Cohen, A.A*. (2022). The Danaid Theory of Aging. Frontiers in Cell and Developmental Biology, 9:671208. https://doi.org/10.3389/fcell.2021.671208. *Both authors contributed equally to this work.
  5. Cohen, A.A., Leblanc, S., Roucou, X. (2021). Robust physiological metrics from sparsely sampled networks. Front. Physiol, 12:624097. https://doi.org/10.3389/fphys.2021.624097
  6. Cohen, A.A., Legault, V., Fulop, T. (2020). What if there’s no such thing as “aging”? Mechanisms of Ageing and Development, 192:111344. https://doi.org/10.1016/j.mad.2020.111344
  7. Cohen, A.A., Kennedy, BK., Anglas, U., Bronikowski, AM., Deelen, J., Dufour, F., Ferbeyre, G., Ferrucci, L., Franceschi, C., Frasca, D., Friguet, B., Gaudreau, P., Gladyshev VN., Gonos, ES., Gorbunova, V., Gut, P., Ivancheko, M., Legault, V., Lemaître, J-F., Liontis, T., Liu, G-H., Liu, M., Maier, AB., Nobrega, OT., Rikkert, M., Pawelec, G., Rheault, S., Senior, AM., Simm, A., Soo, S., Traa, A., Ukraintseva, S., Vanhaelen, Q., Raamsdonk, J., Witkowski, J., Yashin, A., Ziman, R., Fulop, T. (2020). Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework. Mechanisms of Ageing and Development, 191:111316. https://doi.org/10.1016/j.mad.2020.111316
  8. Cohen, A.A., Levasseur M, Raina P, Fried LP, Fülöp T. (2020). Is aging biology ageist? Journal of Gerontology: Biological Sciences, 75(9): 1653-1655. https://doi.org/10.1093/gerona/glz190
  9. Cohen, A.A., Coste, C., Li, X-Y, Bourg, S., and Pavard, S. (2020). Are trade-offs really the key drivers of aging and lifespan? Functional Ecology, 34(1):153–166. https://doi.org/10.1111/1365-2435.13444
  10.  Dansereau, G., Wey, T.W., Legault, V., Brunet, M.A., Kemnitz, J.W., Ferrucci, L., Cohen, A.A. (2019). Conservation of physiological dysregulation signatures of aging across primates. Aging Cell, 18(2): e12925. https://doi.org/10.1111/acel.12925
  11. Cohen, A.A., Legault, V., Fuellen, G., Fulop, T., Fried, L.P., Ferrucci, L. (2018). The risks of biomarker-based epidemiology: Associations of circulating calcium levels with age, mortality, and frailty vary substantially across populations. Experimental Gerontology, 107: 11-17. https://doi.org/10.1016/j.exger.2017.07.011
  12. Cohen, A.A., Isaksson, C., Salguero-Gómez, R. (2017). Co-existence of multiple trade-off currencies has major impacts on evolutionary outcomes. PLOS ONE, 12(12):e0189124. https://doi.org/10.1371/journal.pone.0189124
  13. Cohen, A.A. (2017). Aging across the tree of life: the importance of a comparative perspective for the use of animal models in aging. BBA - Molecular Basis of Disease, 1864:2680-2689. https://doi.org/10.1016/j.bbadis.2017.05.028
  14. Cohen, A.A. (2016). Complex systems dynamics in aging: new evidence, continuing questions. Biogerontology, 17(1):205-20. https://doi.org/10.1007/s10522-015-9584-x
  15. Li, Q., Wang, S., Milot, E., Bergeron, P., Ferrucci, Fried, L.P., Cohen, A.A. (2015). Homeostatic dysregulation proceeds in parallel in multiple physiological systems. Aging Cell, 14(6):1103-12. https://doi.org/10.1111/acel.12402
  16. Cohen, A.A., Milot, E., Li, Q., Bergeron, P., Poirier, R., Dusseault-Bélanger, F., Fulop, T., Leroux, M., Legault, V., Metter, E.J., Fried, L.P., Ferrucci, L. (2015). Detection of a novel, integrative aging process suggests complex physiological integration. PLoS ONE, 10(3): e0116489. https://doi.org/10.1371/journal.pone.0116489
  17. Barnwell-Ménard, JL., Li, Q., and Cohen, A.A. (2015). Effects of categorization method, regression type, and variable distribution on the inflation of Type-I error rate when categorizing a confounding variable. Statistics in Medicine, 34(6): 936-949. https://doi.org/10.1002/sim.6387
  18. Milot, E., Cohen, A.A., Vézina, F., Buehler, D. M., Matson, K. D. & Piersma, T. (2014). A novel integrative method for measuring body condition in ecological studies based on physiological dysregulation. Methods in Ecology and Evolution, 5: 146-155. https://doi.org/10.1111/2041-210X.12145
  19. Morrisette-Thomas, V., Cohen, A.A., Fulop, T., Riesco, E., Legault, V., Li, Q., Milot, E., Dusseault-Bélanger, F., Ferrucci, L. (2014). Inflammaging does not simply reflect increases in pro‐inflammatory markers. Mechanisms of Ageing and Development, 139: 49-57. https://doi.org/10.1016/j.mad.2014.06.005
  20. Cohen, A.A., Milot, E., Li Q., Legault, V., Fried, L.P., Ferrucci, L. (2014). Cross-population validation of statistical distance as a measure of physiological dysregulation during aging. Experimental Gerontology, 57; 203-210. https://doi.org/10.1016/j.exger.2014.04.016
  21. Cohen, A.A., Milot, E., Yong, J., Seplaki, C.L., Fulop, T., Bandeen-Roche, K. & Fried, L. P. (2013). A Novel Statistical Approach Shows Evidence for Multi-system Physiological Dysregulation During Aging. Mechanisms of Ageing and Development, 134(3-4):110-7. https://doi.org/10.1016/j.mad.2013.01.004
  22. Cohen, A.A., Martin, L.B., Wingfield, J.C., McWilliams, S.R. (2012). Physiological Regulatory Networks: Ecological Roles and Evolutionary Constraints. Trends in Ecology and Evolution 27 (8): 428-435. https://doi.org/10.1016/j.tree.2012.04.008
  23. Cohen, A.A., McGraw, K.J., Wiersma, P., Williams, J.B., Robinson, W.D., Robinson, T.R., Brawn, J.D., and Ricklefs, R.E. (2008). Interspecific Associations Between Circulating Antioxidant Levels and Life History Variation in Birds. The American Naturalist 172(2): 178-193. https://doi.org/10.1086/589456
  24. Cohen, A.A. (2004). Female Post-Reproductive Lifespan: A General Mammalian Trait. Biological Reviews, 79: 733-750. https://doi.org/10.1017/s1464793103006432

 

PubMed Bibliography