Current Grant Funding
"Genetic basis for persistence of Borrelia burgdorferi"
09/20/23 to 08/31/28
The experiments in this proposal will examine the roles of the immune response and genetics play in the development of this persistent disease and use novel state of the art tests for detection of Borrelia burgdorferi in patients with post-treatment Lyme disease syndrome.
"Investigation and treatment of undagnosed neuroinflammatory diseases"
12/01/20 to 04/30/26
Clinical cases of undiagnosed neuroinflammatory disease will be evaluated using VirCapSeq-VERT, BacCapSeq, and serology to test for the presence of infectious agents.
"Post exertion malaise in GWI: Brain, autonomic and behavioral interactions"
09/30/19 to 08/31/25
36C24E19D0034 (DoD/Veteran's Affairs)
To determine changes in physiological systems in patients with Gulf War Illness by searching for transcriptomic, proteomic, and metabolomic biomarkers following exercise challenge testing.
"Direct detection of tick-borne agents in a single point-of-care test"
08/01/23 to 07/31/25
To advance diagnostics for tick-borne diseases by transferring capture sequence technology with high specificity for tick-borne agents to a small portable point of care platform that is FDA approved and CLIA-certified.
"GAPP: Global Alliance for Preventing Pandemics"
05/01/20 to 03/31/25
20-45017 (Skoll Foundation)
The objective is to establish an international infrastructure for microbial discovery, surveillance, diagnostics, and response through capacity building at public health laboratories. Research questions that focus on the pathogenesis of unexplained febrile illnesses and cross-species transmission of infectious diseases will be pursued. (Note: this was the prior name for this award was GIDEoN: Global Infectious Disease Epidemiology Network)
"Diagnosing and predicting risk in children with SARS-CoV-2-related illnesses"
11/01/22 to 10/31/24
The research will address the biology and mechanisms of childhood COVID-19 disease and Multisystem Inflammatory Syndrome in Children. We will investigate diagnostic and prognostic testing, antibody repertoires and clinical parameters using clinical samples from children with SARS-CoV-2-related illnesses, Kawasaki disease, and other inflammatory conditions.
"Center for Solutions for ME/CFS"
09/01/22 to 08/31/24
4U54AI138370-06 (GG013887) (NIH/NIAID)
09/22/17 to 08/31/24
4U54AI138370-06 (GG014214) (NIH/NIAID)
The Center for Solutions for ME/CFS – a multi-institutional, inter-disciplinary research center is dedicated to understanding the biology of ME/CFS and developing diagnostic tests and methods for preventing and treating disease.
"TickDx: a comprehensive, rapid, inexpensive serologic platform for diagnosis of tick-borne diseases"
08/01/22 to 08/01/24
NYSDED 134923 (New York State Economic Development Corporation)
Building upon our development of a peptide-based array for tick-borne diseases, we aim to build a cost-effective Luminex-based diagnostic assay for tick-borne diseases that is commercially viable.
"Asian and American centers for arbovirus research and enhanced surveillance (A2CARES)"
07/01/21 to 06/30/24
Analysis of samples collected from the A2CARES program using VirCapSeq-VERT, BacCapSeq, and serological arrays.
"VirCapSeq: A platform for detection of pandemic threats and differential diagnosis of infectious diseases"
03/01/22 to 03/01/24
75A50122C00012 (Office of the Assistant Secretary of Preparedness and Response/DHHS)
VirCapSeq is a capture sequence platform that is under development for clinical diagnostic uses. In this project, we will perform validation studies for the detection of respiratory viruses in a clinical setting. We will seek guidance from the FDA and design a strategy for FDA approval of VirCapSeq as a diagnostic assay.
"Infectious disease surveillance and response in Zambia and Southern Africa"
01/01/22 to 12/31/23
CU21-4079 (Moore Charitable Foundation)
The Global Alliance for Pandemic Preparedness trains scientists in the developing world in laboratory science, epidemiology, and data analysis as part of a larger effort to create an international scientific network that will be prepared to detect future pandemics. Zambia is an increasingly important spot on the African continent for infectious disease surveillance. We will establish a training program with surveillance and research laboratories within Zambia.
"Development of therapeutic fusion inhibitor peptides for Measles encephalitis"
01/01/18 to 09/30/23
R01NS105699 (Submitted for competitive renewal)
The project will lead to a full understanding of the mechanism and risks of MV adaptation to NCS tropism, and to a stable, easily transported intranasal antiviral to protect people at risk during MV outbreaks.
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