Ronald Glabonjat, PhD
- Assistant Professor of Environmental Health Sciences at CUMC
Overview
My current research focusses on elemental speciation analysis of environmental chemicals, and how high-quality analytical methods can contribute to our understanding of exposure sources, metabolic pathways, and potential health effects. My research goals merge into improving the general health of populations, focusing particularly on disproportionally affected communities and to reduce environmental health disparities in underserved populations. My past and current research interests are directed towards advancing our understanding of the biochemical cycles of metals, metalloids, and biomolecules thereof. My focus lays on their interactions with and consequences for human health after environmental exposure. I am particularly interested in the quantitative analysis of metalloids, especially those bound into organic molecules, and how the analytical data can inform us about the biogeochemical pathways and distribution of these contaminants, their toxicity, and their connection to human diseases. In my current work, I focus on the development and application of methods for the simultaneous and time-efficient determination of various health-relevant chemical elemental species.
Academic Appointments
- Assistant Professor of Environmental Health Sciences at CUMC
Credentials & Experience
Education & Training
- BSc, 2012 University of Graz
- MSc, 2013 University of Graz
- PhD, 2017 University of Graz
Research
Research Interests
- Biostatistical Methods
- Environmental Health
- Public Health Education
Selected Publications
Glabonjat R.A., Kitsera M., Unterhauser K., Lembacher-Fadum C., Hoegenauer C., Raber G., Breinbauer R., Zechner E. (2020) Simultaneous quantification of enterotoxins tilimycin and tilivalline in biological matrices using HPLC high resolution ESMS2 based on isotopically 15N-labelled internal standards. Talanta 22, 121677.
Al Amin M.H., Xiong C., Glabonjat R.A., Francesconi K.A., Oguri T., Yoshinaga J. (2018) Estimation of daily intake of arsenolipids in Japan based on a market basket survey. Food and Chemical Toxicology 118, 245–251.
Glabonjat R.A., Raber G., Jensen K.B., Guttenberger N., Zangger K., Francesconi K.A. (2017) A 2-O-methylriboside unknown outside the RNA world contains arsenic. Angewandte Chemie International Edition 56, 11963–11965.
Zheng Y., Tian C., Dong L., Tian L., Glabonjat R.A., Xiong C. (2021) Effect of arsenic-containing hydrocarbon on the long-term potentiation at Schaffer Collateral-CA1 synapses from infantile male rat. Neuro Toxicology 84, 198–207.
Kienesberger S., Cosic A., Kitsera M., Raffl S., Hiesinger M., Leitner E., Halwachs B., Gorkiewicz G., Glabonjat R.A., Raber G., Lembacher-Fadum C., Breinbauer R., Schild S., Zechner E.L. (2022) Enterotoxin tilimycin from gut-resident Klebsiella promotes mutational evolution and antibiotic resistance in mice. Nature Microbiology 7, 1834¬–1848.
Finke H., Wandt V.K., Ebert F., Guttenberg N., Glabonjat R.A., Stiboller M., Francesconi K.A., Raber G., Schwerdtle T. (2020) Toxicological assessment of arsenic containing phosphatidylcholines in HepG2 cells. Metallomics 12, 1159¬–1170.
Drobyshev E., Raschke S., Glabonjat R.A., Bornhorst J., Ebert F., Kuehnelt D., Schwerdtle T. (2021) Capabilities of selenoneine to cross the in vitro blood–brain barrier model. Metallomics 13, mfaa007.
Unterhauser K., Poeltl L., Schneditz G., Kienesberger S., Glabonjat R.A., Kitsera M., Pletz J., Josa-Prado F., Dornisch E., Lembacher-Fadum C., Roier S., Gorkiewicz G., Lucena D., Barasoain I., Kroutil W., Wiedner M., Loizou J.I., Breinbauer R., Díaz J.F., Schild S., Hoegenauer C., Zechner E.L. (2019) Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubule-stabilizing activities. Proceedings of the Natural Academic Society 116, 3774–3783.
Glabonjat R.A., Kitsera M., Unterhauser K., Lembacher-Fadum C., Hoegenauer C., Raber G., Breinbauer R., Zechner E. (2020) Simultaneous quantification of enterotoxins tilimycin and tilivalline in biological matrices using HPLC high resolution ESMS2 based on isotopically 15N-labelled internal standards. Talanta 22, 121677.
Domingo-Relloso A., Makhani K., Riffo-Campos A.L., Tellez-Plaza M., Klein K.O., Subedi P., Zhao J., Moon K.A., Bozack A.K., Haack K., Goessler W., Umans J.G., Best L.G., Zhang Y., Herreros-Martinez M., Glabonjat R.A., Schilling K., Galvez-Fernandez M., Kent Jr. J.W., Sanchez T.R., Taylor K.D., Johnson W.C., Durda P., Tracy R.P., Rotter J.I., Rich S.S., Van Den Berg D., Kasela S., Lappalainen T., Vasan R.S., Joehanes R., Howard B.V., Levy D., Lohman K., Liu Y., Fallin M.D., Cole S.A., Mann K.K., Navas-Acien A. (2022) Arsenic exposure, blood DNA methylation, and cardiovascular disease. Circulation Research 131, e51-e69.