Functional Genetics Boot Camp (live-stream, virtual)

Computational Integration of Genome and Transcriptome Data
10:00 am
5:00 pm
Add to Calendar:
Live-stream, virtual training.
Tuuli Lappalainen, PhD, Columbia; Francois Aguet, PhD, Broad Institute; Yufeng Shen, PhD, Columbia
Towfique Raj, PhD, Icahn School of Medicine at Mount Sinai
Department of Environmental Health Sciences
Open to the Public

**Due to the uncertainty in the coming months around COVID-19, we are transitioning the Functional Genetics Boot Camp to a live-stream, virtual training for this summer. With so many conferences and events being cancelled, we hope that offering this training to be “in-person” via a live-stream, remote format will allow our scientific community to continue learning and developing professionally together. We are working hard on integrating these hands-on skills to an interactive online format.**

The Functional Genetics Boot Camp is a two-day intensive boot camp of seminars and hands-on analytical sessions to provide an overview of concepts and data analysis methods for computational integration of genome and transcriptome data to characterize molecular effects of genetic variants.

Genetic studies in humans have led to discovery of thousands of loci and variants that associate to diverse traits and diseases. However, especially for variants in the noncoding genome, interpretation of functional effects of these variants has been a challenge. One of the approaches to address this challenge has been large-scale analysis of functional genomics data from human samples.

This two-day intensive workshop will provide a rigorous introduction to concepts and analytical methods to map and characterize molecular effects of genetic variants by integration of large-scale genetic and transcriptome data. Led by world experts in functional genomics, human genetics, and statistical methods development, the workshop will integrate seminar lectures with hands-on computer lab sessions to put concepts into practice. The workshop will focus on genetic effects on gene regulation, and guide the participants not only in analytical methods but also the use of major resource data sets like GTEx.

By the end of the workshop, participants will be familiar with the following topics:
- Genetic association to gene expression by eQTL analysis
- Allele-specific expression analysis
- Basics of processing of population-scale RNA-seq data sets
- Integration of GWAS and eQTL data
- Genetic effects on other epigenomic and transcriptomic traits
- Functional interpretation of rare disease-associated variants

Investigators at all career stages are welcome to attend, and we particularly encourage trainees and early-stage investigators to participate.

There are three prerequisites/requirements to attend this training:

1. Each participant must have an introductory background in human genetics and genomics (genetic variants, GWAS, gene expression)
2. Each participant must be familiar with R.
3. Each participant must bring a laptop with R downloaded and installed prior to the first day of the workshop. R is available for free download and installation on Mac, PC, and Linux devices.

If you have any specific questions about R in the context of the Functional Genetics Boot Camp, please email us: Columbia.FunctionalGenetics [at]

Capacity is limited. Registration is required to attend.


JoAnn Schneider, MPA