Lee Goldman, MD, MPH, is the Harold and Margaret Hatch Professor and Executive Vice President for Health and Biomedical Sciences at Columbia University, where he also serves as Dean of the Faculties of Health Sciences and Medicine at Columbia University Medical Center. Dr. Goldman received his undergraduate and medical degrees from Yale University, where he also earned a Masters degree in Public Health. He did his clinical training in medicine at UCSF and Massachusetts General Hospital, and in cardiology at Yale New Haven Hospital. Before joining Columbia he was the Julius R. Krevans Distinguished Professor and Chair of the Department of Medicine and Associate Dean for Clinical Affairs of the School of Medicine at the University of California, San Francisco. Prior to moving to San Francisco, he served as Professor of Medicine at Harvard Medical School, Professor of Epidemiology at Harvard School of Public Health, and Vice Chair of the Department of Medicine and later Chief Medical Officer at Brigham and Women's Hospital. Dr. Goldman's research has focused on the costs and effectiveness of diagnostic and therapeutic strategies, with special emphasis on how the delivery of medical care can be improved based on the results of high-quality clinical investigation. Dr. Goldman is best known for his pioneering work in applying the latest methods of multivariate analysis, cost-effectiveness, quality-of-life, and computer-simulation models to key topics in clinical medicine. This work at the interface between 'public health school methods' and clinical medicine is exemplified by his work predicting the cardiac risk of non-cardiac surgery (the 'Goldman Index'), determining which patients with chest pain require hospital admission ('the Goldman Criteria'), establishing priorities for the prevention and treatment of coronary disease (the Coronary Heart Disease Policy Model), and changing the way medical care is delivered (the scientific basis for the now ubiquitous chest-pain evaluation units and the creation of the first academic hospitalist program). His more than 450 publications include more than 20 first- or senior-authored articles in the New England Journal of Medicine, the premier journal for patient-oriented research. The more than 45 trainees who have first-authored peer-reviewed publications under his mentorship include many who are now leaders in cardiology, general internal medicine, and public health nationally and internationally. As a creator of the Harvard Program in Clinical Effectiveness (Nature 1994;371:100), he has contributed to the training of hundreds of physician investigators and developed approaches that served as one of the models for the National Institutes of Health's K-30 program, which now provides analogous training to patient-oriented researchers at numerous academic medical centers throughout the country. Dr. Goldman is a member of the American Society for Clinical Investigation.